11/24
2023
Seminar
- Title题目 Superselectivity comes from multivalency
- Speaker报告人 夏秀杨 (Nanyang Technological University)
- Date日期 2023年11月24日 10:00
- Venue地点 北楼322
Abstract摘要
The foundation of numerous biological processes lies in the utilization of multiple weak connections to effectively establish strong interactions, a phenomenon known as multivalent interactions. This not only strengthens binding but also leads to the super-linear increase in adsorption of guests with environmental parameter changes, a phenomenon termed superselectivity [1]. Superselectivity plays a pivotal role in determining the fate of nano-medicines in biological environments, client recruitment in biomolecular condensates, and DNA array detection assays, etc. In this talk, I will provide a comprehensive understanding of the superselectivity of both direct multivalent binding [1,2] and indirect linker-mediated bridging [3]. I will illustrate an unexpectedly high receptor concentration-dependent selectivity that occurs under uniform receptor distributions in direct multivalent binding. Additionally, I will discuss the design principles of bridging energy and linker density-dependent superselectivity in indirect linker-mediated bridging.
[1] F. J. Martinez-Veracoechea and D. Frenkel, PNAS 108, 10963 (2011).
[2] X. Xia, G. Zhang, M. Pica Ciamarra, Y. Jiao, and R. Ni, JACS Au 3, 1385 (2023).
[3] X. Xia, and R. Ni, arXiv:2310.15834 (2023).
邀请人：
孟凡龙 研究员
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